Hi, I'm Brian Weitzner, a graduate student in Jeff Gray's lab at the Johns Hopkins University.
Brian Weitzner is a graduate student in the Gray Lab at the Johns Hopkins University who is studying protein structure and protein-protein interactions. Brian's work focuses mainly on antibody structure prediction, particularly in developing novel approaches to accurately predicting long CDR H3 loops. Brian is actively involved in the continued development of the Rosetta software suite and PyRosetta.
Some things I've done:
- Member of STEM Outreach Team, a volunteer program to educate and excite children in Baltimore in the fields of science, technology, engineering and math. (2009-present)
- Member, Rosetta XRW Team to overhaul the structure of the source code (2010-2011)
- American Institute of Chemists Student Award (2009)
- 1st place in national AIChE Car Competition and first team to ever perform perfectly (2008)
- Captain of AIChE Chemical Engineering Car Team (2008-2009)
- Howard Hughes Medical Institute Student Scientist Program, Fox Chase Cancer Center (2004-2005)
- Baugh, E. H., Lyskov, S., Weitzner, B., Gray, J.J. 2011 “Real-time PyMOL visualization for Rosetta and PyRosetta,” PLoS One 6(8):e21931, PMCID: PMC3156697.
- Chaudhury, S., Berrondo, M., Weitzner, B., Muthu, P., Bergman, H., Gray, J.J. 2011 “Benchmarking and analysis of protein docking performance in Rosetta v3.2,” PLoS One 6(8): e22477, PMCID: PMC3149062.
- Bourne, P.E., Beran, B., Bi, C., Bluhm, W., Dunbrack, R., Prlic, A., Quinn, G., Rose, P., Shah, R., Tao, W., Weitzner, B., Yukich, B. 2010 “Will Widgets and Semantic Tagging Change Computational Biology?” PLoS Comput. Biol. 6(2): e1000673, PMCID: PMC2829027.
- Weitzner, B., Meehan, T., Xu, Q., Dunbrack, R. 2009 “An unusually small dimer interface is observed in all available crystal structures of cytosolic sulfotransferases,” Proteins: Structure, Function, and Bioinformatics 75(2), 1097-0134, PMCID: PMC2728805.
Brian Weitzner's Background
Brian Weitzner's Experience
Student Scientist Research Assistant at Dunbrack Lab, Fox Chase Cancer Center
August 2004 - August 2005 | Philadelphia, PA
Undergraduate Research Assistant at Dunbrack Lab, Fox Chase Cancer Center
May 2006 - August 2009 | Philadelphia, PA
Undergraduate Research Assistant at DeLisa and Varner Labs, Cornell University
October 2006 - May 2009 | Ithaca, NY
Graduate Research Assistant at Gray Lab, Johns Hopkins University
August 2009 - Present | Baltimore, MD
Teaching Assistant under T. Michael Duncan: ChemE 1120 - Introduction to Chemical Engineering at Cornell University
August 2008 - December 2008 | Ithaca, NY
Design and analysis of processes involving chemical change. Students learn strategies for design, such as creative thinking, conceptual blockbusting, and (re)definition of the design goal, in the context of contemporary chemical and biomolecular engineering. Includes methods for analyzing designs, such as mathematical modeling, empirical analysis by graphics, and dynamic scaling through dimensional analysis, to assess product quality, economics, safety, and environmental issues.
Teaching Assistant under T. Michael Duncan: ChemE 3900 - Chemical Kinetics and Reactor Design at Cornell University
January 2009 - May 2009 | Ithaca, NY
Chemical Engineers design and analyze processes and products based on chemical change.
The chemical reaction is the essence of any chemical product. The chemical reactor is the essence of any chemical process. Reactor Design is the core of Process Design. Other units serve the reactor and/or treat the reactor output. The reactor dictates the type and size of other process units.
Teaching Assistant under Jeffrey J. Gray: ChemBE 414/614 - Computational Protein Structure Prediction and Design at Johns Hopkins University
January 2010 - May 2010 | Baltimore, MD
This class will introduce the fundamental concepts in protein structure, biophysics, optimization and informatics that have enabled the breakthroughs in computational structure prediction and design. Problems covered will include protein folding and docking, design of ligand-binding sites, design of turns and folds, design of protein interfaces.
Teaching Assistant under Jeffrey J. Gray: ChemBE 409 - Modeling, Dynamics and Control of Chemical and Biological Systems at Johns Hopkins University
August 2010 - December 2010 | Baltimore, MD
ChemBE courses typically focus on mathematical models of steady-state behavior; here, the student will learn to model dynamics, that is, responses over time. In particular, the student will model the transient response around a steady-state solution, and design appropriate control systems to maintain desired process behavior. In the chemical process industries, correct process control is essential for safety, environmental security, and economic optimality. In biological systems, complex control loops already exist to maintain homeostasis and enable interesting function.
Co-Instructor with Joelle Frechette: ChemBE 418 - Projects in the Design of a Chemical Car at Johns Hopkins University
August 2011 - December 2011 | Baltimore, MD
Ready to put those concepts from class into practice? Members work over the course of the semester to design and build a chemically powered vehicle that will compete with other college teams at the American Institute of Chemical Engineers ( AIChE) Regional Conference. In this course, the students work in small groups to design and construct the chassis along with chemically powered propulsion and break mechanisms within the constraints of the competition. In addition, students will give oral presentation, write reports, and do thorough safety analysis of their prototypes.
Brian Weitzner's Education
2005 – 2009
B.S. Chemical and Biomolecular Engineering, Minor Biomedical Engineering
Activities: AIChE Chemical Engineering Car Team
Johns Hopkins University
2009 – 2014
Ph.D. Chemical and Biomolecular Engineering
Concentration: Protein Structure and Protein-Protein Interaction Prediction
Brian Weitzner's Interests & Activities
Snowboarding, live music, running, coffee, brewing beer. You know, normal stuff.